FeOOH-loaded mesoporous silica nanoparticles as a theranostic platform with pH-responsive MRI contrast enhancement and drug release

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（7）
• 页码范围: 806-811
• 页数: 6页
• 语种: 英文

摘要

The development of stimuli-responsive theranostic platforms is of great demand for efficient cancer treatment because they can enhance diagnostic specificity and sensitivity.In this work,we report a pH-responsive theranostic nanoplatform based on FeOOH clusters loaded mesoporous silica nanoparticles (Fe@MSNs).The as-synthesized Fe@MSNs possess activatable T1 magnetic resonance imaging (MRI) performance that can respond to the acidic microenvironment of solid tumor to turn on T1 singals by releasing paramagnetic Fe3+ ions.The Fe@MSNs are biocompatible without appreciable cytotoxicity.Moreover,the unique mesoporous structure endows the Fe@MSNs with significant advantages to effectively deliver chemotherapeutic drug for inhibiting the growth of solid tumor.We believe that this novel pH-responsive theranostic nanoplatform holds great promise in cancer treatment.