The Mechanism of Cortico-Striato-Thalamo-Cortical Neurocircuitry in Response Inhibition and Emotional Responding in Attention Deficit Hyperactivity Disorder with Comorbid Disruptive Behavior Disorder

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2018,（3）
• 页码范围: 566-572
• 页数: 7页
• 语种: 英文

摘要

The neurocircuitries that constitute the corticostriato-thalamo-cortical (CSTC) circuit provide a framework for bridging gaps between neuroscience and executive function in attention deficit hyperactivity disorder (ADHD),but it has been difficult to identify the mechanisms for regulating emotional problems from the understanding of ADHD comorbidity with disruptive behavior disorders (DBD).Research based on “cool” and “hot” executive functional theory and the dual pathway models,which are thought of as applied response inhibition and delay aversion,respectively,within the neuropsychological view of ADHD,has shed light on emotional responding before and after decontextualized stimuli,while CSTC circuit-related domains have been suggested to explain the different emotional symptoms of ADHD with or without comorbid DBD.This review discusses the role of abnormal connections in each CSTC circuit,especially in the emotion circuit,which may be responsible for targeted executive dysfunction at the neuroscience level.Thus,the two major domains-abstract thinking (cool) and emotional trait (hot)-trigger the mechanism of onset of ADHD.