Competing for enhancers: PVT1 fine-tunes MYC expression

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2018,（8）
• 页码范围: 785-786
• 页数: 2页
• 语种: 英文

摘要

Cho and colleagues uncover a novel mechanism of transcriptional repression of MYC which attributes a tumor-suppressive role to the neighboring PVT1 promoter, and shed light on recurrent chromosomal rearrangements within the MYC locus. In human cells, chromatin is three-dimensionally organized into discrete self-interacting units called topologically associating domains (TADs). TADs are generally preserved across cell lineages and their boundaries are enriched for binding sites of ubiquitous architectural proteins (e.g., CTCF, cohesins, etc.). These domain boundaries are referred to as chromatin "insulators" as they confine enhancer activity within specified TADs. Dynamic looping interactions within a TAD scaffold, or intra-TAD loops, enable finer regulation of enhancer-promoter pairs in different tissue types1.