IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice

• 来源期刊: 中国药理学报（英文版）
• 关键词: cancer metastasis lymphatic metastasis IR-780 polymeric micelles photothermal therapy
• 年，卷（期）: 2018,（1）
• 页码范围: 132-139
• 页数: 8页
• 语种: 英文
• DOI: 10.1038/aps.2017.109

摘要

Cancer metastasis is responsible for over 90％ of breast cancer-related deaths,and inhibiting lymph node metastasis is an option to treat metastatic disease.Herein,we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis.The IPMs were nanometer-sized micelles with a mean diameter of 25.6 nm and had good stability in simulated physiological solutions.Under 808-nm laser irradiation,IPMs exhibited high heat-generating capability in both in vitro and in vivc experiments.After intravenous injection,IPMs specifically accumulated in the tumor and metastatic lymph nodes and penetrated into these tissues.Moreover,a single IPMs treatment plus laser irradiation significantly inhibited primary tumor growth and suppressed lymphatic metastasis by 88.2％.Therefore,IPMs are an encouraging platform for PTr applications in treatment of metastatic breast cancer.