Applications of CBT-Cys click reaction: past, present, and future

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（9）
• 页码范围: 1088-1098
• 页数: 11页
• 语种: 英文

摘要

Herein,we review the development,applications and potential prospects of CBT-Cys click reaction.This click condensation reaction is based on the condensation reaction between 2-cyanobenzothiazole (CBT) and D-cysteine (D-Cys) in fireflies and has high biocompatibility and controllability in physiological solutions.Under the control of pH,reduction,or enzyme,this CBT-based click reaction has been widely applied to a wide range of biomedical fields such as protein labeling,molecular imaging (e.g.,optical imaging,nuclear imaging,magnetic resonance imaging and photoacoustic imaging),nanomaterial fabrication,cancer therapy,and other potentialities.