Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2018,（8）
• 页码范围: 868-870
• 页数: 3页
• 语种: 英文

摘要

Dear Editor, Foci of cell death are commonly observed in core regions of solid tumors as a result of inadequate vascularization and subsequent metabolic stresses such as hypoxia and glucose deprivation. Since the morphology of dead tumor cells appears to be necrotic, it is often referred as tumor necrosis. Tumor necrosis has been found to be associated with tumorigenesis and poor prognosis for years,1 but the role of necrosis in tumor development is still largely unknown. Additionally, the molecular mechanism of necrosis is an under-studied area due to the lack of experimental system for manipulating necrotic cell death. Necroptosis is a form of programmed, caspase-independent necrosis.2 Studies on TNF-induced necroptosis have improved our understanding on the molecular mechanism of necroptosis. It is now known that the protein kinases receptor interacting protein kinase 1 (RIPK1), RIPK3 and the mixed lineage kinase domain-like(MLKL) constitute the core of the necroptosis machinery.3-5