Comprehensive base editing mediated by hAPOBEC3A-conjugated base editors

• 来源期刊: 中国科学基金（英文版）
• 年，卷（期）: 2018,（4）
• 页码范围: 36
• 页数: 1页
• 语种: 英文

摘要

With the support by the National Natural Science Foundation of China,the research teams led by Prof.Yang Li (杨力) at the CAS Key Laboratory of Computational Biology,CAS-MPG Partner Institute for Computational Biology,and Prof.Chen Jia (陈佳) and Prof.Huang XingXu (黄行许),at the School of Life Science and Technology,ShanghaiTech University,developed a series of human APOBEC3A-conjugated base editors (BEs) to achieve comprehensive C-to-T base editing in all tested regions,including the regions with high methylation levels.This work was published in Nature Biotechnology (2018,36:946-949).