Bipolar electrochemistry in confined nanospace

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（4）
• 页码范围: 379-380
• 页数: 2页
• 语种: 英文

摘要

Nanopores employ a confined space for electrochemical seining of high-throughput individual biomolecules in solution.The most general mechanism of nanopore sensing is based on a volume exclusion effect.However,the increasing demands on revealing the single-molecule/particle chemistry and biophysics require the nanopores not only provide structural/conformational/sequencing information,but also directly read the dynamic functional properties of single molecules/particles.The traditional design ofnanopores (e.g.SiN,quartz nanopipette and biological nanopores) lacks an electrochemically active interface to detect both ionic flux and the accompanying faraday current.Given that,Ying and Long [1-3] proposed a new concept of electrochemically confined effects for the sophisticated design of a wireless nanopore electrode (WNE).The WNE possesses a metal layer on the inner wall of the asymmetric nanopipette,which is easy to be polarized under the electric field to provide a controllable electroactive interface (Figure 1).