SIRT1 rs3758391 and Major Depressive Disorder: New Data and Meta-Analysis

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2018,（5）
• 页码范围: 863-866
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, It is known that genetic factors play important roles in the pathophysiology of major depressive disorder (MDD).However,its genetic mechanism is still unknown.Recently,the CONVERGE consortium performed wholegenome sequencing in a homogenous Chinese sample (5303 MDD patients and 5337 controls) and one locus near the silent mating type information regulation 2 homolog 1 gene (SIRT1) was identified at a genome-wide significant level [1].At the mRNA level,we found that SIRT1 expression is significantly down-regulated in the peripheral blood of patients with MDD compared with healthy participants (decreased by 37％) [2].As such,this suggests that SIRT1 is a novel MDD risk gene in Han Chinese.