Changes of QT Dispersion in Hemodialysis Patients after Administrating Zhigancao Decoction (炙甘草汤)

• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2018,（8）
• 页码范围: 627-631
• 页数: 5页
• 语种: 英文
• DOI: 10.1007/s11655-016-2599-6

摘要

Objective:To observe the alteration of QT dispersion (QTd) and QTc dispersion (QTcd) in hemodialysis patients after oral administration of Zhigancao Decoction (炙甘草汤,Roasted Licorice Decoction,RLD).Methods:To investigate the alteration of QTd and QTcd in 68 routine hemodialysis patients before and after hemodialysis with 12-lead electrocardiogram (ECG) after orally administrated RLD for 4 weeks.Blood was also taken for measurement of plasma electrolytes,liver function,renal function,hemoglobin (Hgb) and hematocrit (HCT).Results:After hemodialysis,QTd and QTcd were prolonged evidently;the difference was significant between before and after hemodialysis (P＜0.05).After RLD orally administrated for 4 weeks,QTd and QTcd only slightly increased after dialysis compared with pre-dialysis (P＞0.05).The QTd and QTcd of the post-therapy-post-dialysis decreased significantly compared with the pre-therapy-post-dialysis (P＜0.05).There were no other significant changes in other variables (post-therapy-pre-dialysis vs.pre-therapy-pre-dialysis,or post-therapy-post-dialysis vs.pre-therapy-post-dialysis;P＞0.05).After therapy,the number of patients with supraventricular arrhythmia,occasional ventricular premature beat and multiple ventricular premature beat were decreased from 15 to 4,10 to 2 and 7 to 1,respectively.Conclusion:RLD therapy not only lowered the increased QTd and QTcd after hemodialysis,but also displayed a safety profile.