The Mitochondrion: A Potential Therapeutic Target for Alzheimer's Disease

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2018,（6）
• 页码范围: 1127-1130
• 页数: 4页
• 语种: 英文

摘要

Introduction The mitochondrion is a double-membrane organelle consisting of an outer membrane,intermembrane space,inner membrane,cristae,and matrix.It is the "energy plant" that provides most of the energy for cells.Mitochondria also participate in various processes such as calcium homeostasis,cell death,and cell growth during development and aging [1].Mitochondrial abnormalities are a common phenomenon in aging and age-related neurodegenerative diseases such as Alzheimer's disease (AD).Mitochondrial dysfunction is even taken to be a marker for aging,an indispensable risk factor for AD [1].Anti-oxidants and factors that maintain mitochondrial homeostasis have beneficial effects in AD therapy.Thus,the mitochondrion is emerging as a novel target for AD therapy.