Synthesis and anti-inflammatory activity of gold-nanoparticle bearing a dermatan sulfate disaccharide analog
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摘要:
A dermatan sulfate (DS) repeating disaccharide analog,α-L-idopyranosiduronate-(1 →3)-2-amino-2-deoxy-4,6-di-O-sulfo-β-D-galactopyranoside,has been convergently synthesized and successfully applied to prepare the GAG-functionalized gold glyconanoparticle.This new material exhibited good anti-inflammatory activity which was comparable to that of the drug ibuprofen incarrageenan-induced paw edema in a rat model.