A smart supramolecular phototherapeutics for specific cancer therapy

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（11）
• 页码范围: 1353-1354
• 页数: 2页
• 语种: 英文

摘要

Phototherapeutics provides opportunities for cancer therapy because of its high spatiotemporal controllability and minimal invasiveness.For example,photodynamic therapeutics,often termed as photosensitizer (PS),can be administered to the patients with subsequent exposure to a specific light that leads to the death of the disease cells via oxidative damage.However,the efficacy of traditional PS has been limited by several issues including poor tumor specificity,fast renal clearance,and phototoxic side effect on normal tissues [1].Activatable phototherapeutics that only turns on its toxic photodynamic or photothermal process in response to the diseases biomarker of interest has emerged as a promising approach towards precision cancer therapy [2].Till now,enzyme-responsive photodynamic and photothermal therapeutics have been reported for cancer therapy [2,3].However,these systems heavily rely on synthetic chemistry and are not easy to be generalized for other therapeutic applications.