A Context-Based Analgesia Model in Rats: Involvement of Prefrontal Cortex

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2018,（6）
• 页码范围: 1047-1057
• 页数: 11页
• 语种: 英文

摘要

Cognition and pain share common neural substrates and interact reciprocally:chronic pain compromises cognitive performance,whereas cognitive processes modulate pain perception.In the present study,we established a non-drug-dependent rat model of context-based analgesia,where two different contexts (dark and bright) were matched with a high (52℃) or low (48℃) temperature in the hot-plate test during training.Before and after training,we set the temperature to the high level in both contexts.Rats showed longer paw licking latencies in trials with the context originally matched to a low temperature than those to a high temperature,indicating successful establishment of a context-based analgesic effect in rats.This effect was blocked by intraperitoneal injection of naloxone (an opioid receptor antagonist) before the probe.The context-based analgesic effect also disappeared after optogenetic activation or inhibition of the bilateral infralimbic or prelimbic sub-region of the prefrontal cortex.In brief,we established a context-based,non-drug dependent,placebo-like analgesia model in the rat.This model provides a new and useful tool for investigating the cognitive modulation of pain.