Structural insights into the CRISPR-Cas-associated ribonuclease activity of Staphylococcus epidermidis Csm3 and Csm6:a step for the development of novel genome editing tool

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2018,（11）
• 页码范围: 672-674
• 页数: 3页
• 语种: 英文
• DOI: 10.1016/j.scib.2018.03.017

摘要

CRISPR-Cas systems has been developed as genome editing tools,which are originally discovered as sequence-specific defense system utilized by bacteria and archaea to fight with the invasion by foreign nucleic acids such as phages or plasmids.According to the current classification groups of CRISPR-Cas system,Type Ⅰ,Type Ⅲ and Type Ⅳ comprise the Class 1 systems for their function through multisubunit Cas protein complex to interference the targeted nucleic acids.