Salvia miltiorrhiza Burge (Danshen): a golden herbal medicine in cardiovascular therapeutics

• 来源期刊: 中国药理学报（英文版）
• 关键词: Salvia miltiorrhiza Burge Danshen cardiovascular diseases herbal medicine traditional Chinese medicine
• 年，卷（期）: 2018,（5）
• 页码范围: 802-824
• 页数: 23页
• 语种: 英文
• DOI: 10.1038/aps.2017.193

摘要

Salvia miltiorrhiza Burge (Danshen) is an eminent medicinal herb that possesses broad cardiovascular and cerebrovascular protective actions and has been used in Asian countries for many centuries. Accumulating evidence suggests that Danshen and its components prevent vascular diseases, in particular, atherosclerosis and cardiac diseases, including myocardial infarction, myocardial ischemia/ reperfusion injury, arrhythmia, cardiac hypertrophy and cardiac fibrosis. The published literature indicates that lipophilic constituents(tanshinone I, tanshinone lla, tanshinone llb, cryptotanshinone, dihydrotanshinone, etc) as well as hydrophiiic constituents (danshensu,salvianolic acid A and B, protocatechuic aldehyde, etc) contribute to the cardiovascular protective actions of Danshen, suggesting a potential synergism among these constituents. Herein, we provide a systematic up-to-date review on the cardiovascular actions and therapeutic potential of major pharmacologically active constituents of Danshen. These bioactive compounds will serve as excellent drug candidates in small-molecule cardiovascular drug discovery. This article also provides a scientific rationale for understanding the traditional use of Danshen in cardiovascular therapeutics.