Palladium-catalyzed oxidative cyclopropanation of enamides and norbornenes initiated by C–H activation

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（6）
• 页码范围: 695-701
• 页数: 7页
• 语种: 英文

摘要

A novel palladium-catalyzed oxidative cyclopropanation of enamides and norbornenes has been developed. The reaction proceeded through palladium-catalyzed vinyl C–H bond activation of enamides followed by two migratory insertions, β- (N) H elimination and hydrolyzation cascade steps. The reaction tolerates a range of functional groups and provides an effective method for the synthesis of cyclopropane-fused norbornanes in good yields under mild conditions.