Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（6）
• 页码范围: 702-707
• 页数: 6页
• 语种: 英文

摘要

Snake toxin Calciseptine as a natural antagonist of L-type calcium channel has potential drug values, but its structural information remains unknown. Here, we report the total chemical synthesis of Calciseptine by using hydrazide based native chemical ligation. The crystal structure of Calciseptine was determined by racemic protein crystallography technique. Compared to the structure of its homologous family protein, we found that Calciseptine is adopting a typical three-finger structure.