Effects of Ionizing Radiation and HLY78 on the Zebrafish Embryonic Developmental Toxicity

• 作者: Si Jing Zhang Hong Zhou Rong
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报:英文版
• 学科: 经济
• 关键词: HLY ALONE ZEBRAFISH
• 年，卷（期）: 2018,（1）
• 页码范围: 160-162
• 页数: 3页
• 分类号: F42

摘要

The health-related effects of ionizing radiation on embryonic development and their underlying mechanisms are still unclear.The aim of this study was to investigate the role of Wnt signaling in mediating the developmental toxicity induced by heavy ion and proton radiation using zebrafish embryos.Wnt signaling is a well-known cell signaling pathway with roles in embryogenesis.Wnt family members can regulate cell fate determination,differentiation,proliferation,and apoptosis during embryonic development[1;2].Zebrafish embryos were radiated with carbon ions or protons.HLY78,an activator of the Wnt signaling pathway,was added immediately after radiation.Carbon ion radiation induced a significant increase of mortality,and activating Wnt signaling using HLY78 after radiation significantly alleviated this stress.Both carbon ion and proton radiation significantly increased malformation rates and decreased hatching rates.Supplementation with HLY78 significantly reduced the effects induced by carbon ion radiation alone(Fig.1).After irradiation with carbon ions,embryos showed a significant decrease in heart rate,spontaneous movement,and locomotive behavior(Figs.2 and 3).Supplementation with HLY78 was able to reduce these effects.The results of this study improve our understanding of the mechanisms of carbon ion radiation-induced developmental toxicity,which potentially involves the inhibition of Wnt signaling.