Kinetic Changes of ATP IF1 Protein in A549 Cell Line of Non-small Cell Lung Cancer after X-ray Irradiation

• 作者: Dou Zhihui Wang Yupei Zhang Hong
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报:英文版
• 学科: 医学
• 关键词: IF1 IMPAIRED LUNG
• 年，卷（期）: 2018,（1）
• 页码范围: 166-167
• 页数: 2页
• 分类号: R73

摘要

It is well established that when mitochondrial respiration is impaired,the H+ATP synthase can function in reverse acting as an ATP hydrolase for maintaining the proton motive force[1].This process is regulated by an inhibitor peptide called ATPase inhibitory factor 1 or IF1,a highly conserved nuclearly encoded protein[2].Since IF1 is highly expressed in most tumors,the significance of IF1 in tumor cells has also been widely studied[3].