Shape linear peptides into rigid rings: a sp3 C-H arylation approach to cyclophane-braced peptide macrocycles

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（12）
• 页码范围: 1477-1478
• 页数: 2页
• 语种: 英文

摘要

Peptide-based therapeutics have attracted increasing attention due to their unique properties in comparison to small molecule drugs and recombinant biologics [1].With moderate size and suitable surface area,peptides possess enormous potential in drug discovery for their promising capabilities of intercepting protein-protein interactions (PPIs),which is extremely difficult to be accomplished using small molecule compounds [2].