Nanopore sensing system for high-throughput single molecular analysis

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（12）
• 页码范围: 1483-1485
• 页数: 3页
• 语种: 英文

摘要

Nanopore technique enables a sensitive,label free,low cost and high throughput method for single-molecule analysis [1-4].Usually,the nanopore is fabricated on an insulating membrane with electrolyte solution in two sides,which can act as the only pathway for the ionic flow.When a single molecule enters the pore under the applied biased potential,it will temporarily block the ionic current flow through the nanopore.By analyzing the amplitude,duration,shape and frequency spectra of ionic current modulations,nanopore detection could provide the characteristics of the analytes including their size,charge,shape and conformation [5].