Osthole Protects Against Microgravity-induced Bone Loss Through Suppressing miR-34c Expression in Hindlimb Suspension Rats

• 作者: Feng Xiu He Jinpeng Hua Junrui Long Kaiqin Wang Jufang Zhang Yanan
• 来源期刊: 中国科学院近代物理研究所和兰州重离子研究装置年报:英文版
• 学科: 医学
• 关键词: protective METABOLISM MODULATOR
• 年，卷（期）: 2018,（1）
• 页码范围: 178-179
• 页数: 2页
• 分类号: R68

摘要

Bone loss is one of the major barriers for human deep space exploration.To date,there has been less effective measures against bone metabolism derangement during long-term spaceflights[1;2].Traditional Chinese Medicine(TCM)has been used for bone and joint diseases for thousands of years.Osthole(OST),an O-methylated coumarin,is originally extracted from the fruits of Cnidium monnieri which is a main osteoporosis treatment agent in TCM.Studies have demonstrated that OST have multiple pharmacological and biological features including neuroprotective,immunomodulatory,anticancer,hepatoprotective,cardiovascular protective,and antimicrobial activities[3].In addition,numerous studies also suggested that OST has better bone protection effects by enhancing the differentiation and maturation of osteoblasts[4;5].However,the functions of OST in regulation of bone loss induced by microgravity remain unclear.