GMP-quadruplex-based hydrogels stabilized by lanthanide ions

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（5）
• 页码范围: 604-612
• 页数: 9页
• 语种: 英文

摘要

This work describes the gelation behaviors and properties of a biological molecule,guanosine 5＇-monophosphate disodium salt (GMP),in the presence of trivalent lanthanide ions.Hydrogels composed of GMP-quadruplexes were prepared by adjusting pH,through which the protonation of phosphate group was controlled to tune the interactions between lanthanide ions and GMP.Within the pH region of 2-6,the electrostatic interaction between lanthanide ions and phosphate group is hindered and the cation-dipole interaction acts as the main driving force for the formation of G-quadruplexes.All the hydrogels were found consisting of three-dimensional network of the intertwining one-dimensional nanofibers formed by the stacking G-quartets induced by lanthanide ions.A significant fluorescence enhancement ofthioflavin T (ThT),a fluorescent molecule,was found to be triggered by the G-quadruplex structures,for which the rotation of chromophoric groups on ThT molecules were prohibited due to the implant into the G-quadruplex structures.