A novel TRPC6-dependent mechanism of TGF-β-induced migration and invasion of human hepatocellular carcinoma cells

• 来源期刊: 中国科学（生命科学）
• 年，卷（期）: 2018,（9）
• 页码范围: 1120-1122
• 页数: 3页
• 语种: 中文

摘要

Mechanisms on cancer cell migration and invasion have been major topics of cancer research and anti-cancer therapy development.Among the multiple cell signaling pathways involved in cell migration,those elicited by transforming growth factor β (TGF-β) have attracted tremendous attention.The TGF-β polypeptide cytokines include four isoforms:TGF-β1,TGF-β2,TGF-β3,and TGF-β4,which are secreted mainly from cells of white blood cell lineage,such as macrophages,T cells and platelets.However,TGF-β can also be synthesized and released from fibroblasts and cancer cells (Shi and Chen,2017).