miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

• 来源期刊: 中国药理学报（英文版）
• 关键词: microRNA cardiovascular diseases biomarker therapeutic targets
• 年，卷（期）: 2018,（7）
• 页码范围: 1073-1084
• 页数: 12页
• 语种: 英文
• DOI: 10.1038/aps.2018.30

摘要

Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the world.Although considerable progress has been made in the diagnosis,treatment and prognosis of CVD,there is still a critical need for novel diagnostic biomarkers and new therapeutic interventions to decrease the incidence of this disease.Recently,there is increasing evidence that circulating miRNAs (miRNAs),i.e.endogenous,stable,single-stranded,short,non-coding RNAs,can be used as diagnostic biomarkers for CVD.Furthermore,miRNAs represent potential novel therapeutic targets for several cardiovascular disorders.In this review we provides an overview of the effects of several CVD;including heart failure,acute myocardial infarction,arrhythmias and pulmonary hypertension;on levels of circulating miRNAs.In addition,the use of miRNA as therapeutic targets is also discussed,as well as challenges and recommendations in their use in the diagnosis of CVD.