Photocaged prodrug under NIR light-triggering with dual-channel fluorescence: in vivo real-time tracking for precise drug delivery

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（10）
• 页码范围: 1293-1300
• 页数: 8页
• 语种: 英文

摘要

Light-triggered drug delivery system is an effective strategy for precise diagnosis and therapy in cancer treatment.However,it suffers from difficultly balancing the dosimetry of drug with light dose and a lack of in vivo models for validating their clinical benefits.Here we report an unprecedented near-infrared (NIR) light photocaged cyanine-based prodrug Cy-CPT-Biotin with dual-channel fluorescence mode,enabling NIR light to precisely regulate where,when and how the intact and active prodrugs are delivered.The synergy of photochemical reaction and modulation in π-conjugated polyene backbone of cyanine can fully perform distinct dual-channel fluorescence changes in a NIR light-mediated manner.The prodrug has striking characteristics of excellent tumor-targeting ability,real-time monitoring of the in vivo behaviors by dual-channel mode and NIR-light triggering,especially for achieving fine regulation and on-demand drug release in the precise dosimetry of drug with light dose in living animals.This optical orthogonality strategy that conjuncts with NIR light-triggered and dual-channel fluorescence in vivo imaging provides a powerful tool for in vivo real-time tracking and finely tnning the prodrug release for precise drug delivery.