Enzyme responsive supramolecular hydrogels assembled from nonionic peptide amphiphiles

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（10）
• 页码范围: 1314-1319
• 页数: 6页
• 语种: 英文

摘要

Smart peptide hydrogels are of great interest for their great potential applications.Here,we report a facile approach to prepare a class of enzyme-responsive hydrogels in a scalable manner.These hydrogels self-assemble from a family of nonionic peptide amphiphiles (PAs) synthesized by sequential ring-opening polymerization (ROP) ofγ-benzyl-L-glutamate N-carboxyanhydride (BLG-NCA) and L-tyrosine N-carboxyanhydride (Tyr-NCA),followed by subsequent aminolysis.These PA samples can readily form a clear hydrogel with a critical gelation concentration as low as 0.5 wt％.The incorporation of tyrosine residues offers hydrophobicity,hydrogen-bonding interaction and enzyme-responsive properties.The hydrogel-to-nanogel transition is observed under physiological conditions in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2).Theobtained PA hydrogels are ideal candidates for the new generation of smart scaffolds.