A cell-permeable green fluorescent probe for dsDNA

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2018,（4）
• 页码范围: 468-475
• 页数: 8页
• 语种: 英文

摘要

The sensitive and selective detection of nucleic acids is important for basic research and many applied fields.Herein,a novel green DEAB-TO-1 was designed and synthesized.DEAB-TO-1 shows significant fluorescence enhancement (800-fold) when bound to ctDNA and a distinct selectivity for dsDNA over RNA (5.9 times).Moreover,the limit of detection is 0.57 ng/mL.It is live-cell-permeant DNA intecalator,indicating a promising candidate for nucleus-specific imaging and a good counter-stain compatibility with other dyes.