Drug combination therapy:providing evidence of significant superiority of a combination of drugs compared to the single agents

• 作者: Xiong-Zhi Wu
• 来源期刊: TMR药物联合治疗
• 学科: 医学
• 关键词: DRUG COMBINATION THERAPY SUPERIORITY
• 年，卷（期）: 2019,（1）
• 页码范围: 1-1
• 页数: 1页
• 分类号: R

摘要

Based on Jun-Chen-Zuo-Shi,traditional Chinese medicine has used mixtures of naturally occurring herbs for more than 2000 years.Since the last century,advances in omics and cell biology have greatly impacted on the increasing use of drug combination in modern medicine.The enhanced understanding of the biology of a disease as a disturbed system of interconnected molecular pathways which are more susceptible to the simultaneous action of several drugs,provides new opportunities for the rational development of combination therapies.Combination therapies exploit the chances for better efficacy,decreased toxicity,and reduced development of drug resistance and owing to these advantages,have become a standard for the treatment of several diseases and continue to represent a promising approach in indications of unmet medical need.