A New Perspective for Chinese Medicine Intervention for Coronary Artery Disease: Targeting Inflammation

• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2019,（1）
• 页码范围: 3-8
• 页数: 6页
• 语种: 英文
• DOI: 10.1007/s11655-018-2995-1

摘要

Inflammation,which plays a critical role in atherosclerosis and the occurrence of acute cardiovascular events,may be a new target for treatment of coronary artery disease (CAD) to reduce residual cardiovascular risk.Recently,Anti-inflammatory Therapy with Canakinumab for Atherrosclerotic Disease (CANTOS),the largest scale clinical trial that targeted inflammation but not lipids,has affirmed for the first time the inflammatory hypothesis of artherosclerosis and marked the advent of an exciting era of targeting inflammation for the prevention and treatment of cardiovascular diseases.Chinese medicine (CM) is a promising adjuvant therapy for CAD in light of its safety and pleiotropic effect of anti-inflammation,anti-platelet,lipid-regulating,endothelium-protection,microcirculation-improving,etc.In recent years,exploration of anti-inflammatory treatment of CAD with CM has been going on from theory to practice.Taking CANTOS as an example,the design strategy to combine CM and Westem medicine to inhibit inflammation were discussed in this paper,which might provide a new perspective for CM intervention on CAD.