Neutrophil-to-Lymphocyte Ratio as a Novel Biomarker in Ischemic Stroke: A Literature Review

• 作者: Bei-Bei Yao Ming-Hua Wu Wen-Wen Du Xiao-Feng Cao Xin Xia
• 来源期刊: 脑血管病电子杂志(英文)
• 学科: 医学
• 关键词: Neutrophil-to-lymphocyte ratio ISCHEMIC STROKE Inflammation Diagnosis STROKE SEVERITY Prognosis
• 年，卷（期）: 2019,（1）
• 页码范围: 5-10
• 页数: 6页
• 分类号: R

摘要

Background: Ischemic stroke accounts for approximately 80% of all cases of stroke and has the highest rates of morbidity,disability,mortality,and recurrence. The neutrophil-to-lymphocyte ratio (NLR) is a novel,feasible marker representing an integrated response to inflammation. The purpose of the current review is to evaluate all available evidence from clinical observational trials about the relationships between NLR and ischemic stroke. Methods: We searched PubMed,Embase,and CNKI for clinical observational trials on NLR published up to August 1,2018,and made a brief summary about the predictive value of the correlation between NLR and ischemic stroke. Results: A high NLR is associated with increased risk of developing stroke and is a new addition to the traditional risk factors of atrial fibrillation and carotid artery stenosis. NLR on admission is an independent predictor of short- and long-term mortality in patients with acute ischemic stroke. In patients receiving recombinant tissue plasminogen activator or endovascular treatments,high NLR was reported with higher mortality or major disability. Conclusion: NLR provides an easy,useful method to predict the incidence,severity,and prognosis of ischemic stroke;thus,it can emerge as a new potential target for anti-inflammatory treatment and development of therapeutic strategies.