Synthesis and Characterization of a New Compound of Cobalt II with Isonicotinamide and Evaluation of the Bactericidal Potential

• 作者: Adenilda Cristina Honorio Fran?a Anderson Dourado Galv?o Claudia Cristina de Sousa Eduardo Luzía Fran?a Fabricio Tarso de Moraes Kátia Meirelles Duarte de Sousa Patrícia Gelli Feres de Marchi Wagner Batista dos Santos
• 来源期刊: 无机化学期刊(英文)
• 学科: 化学
• 关键词: COBALT ISONICOTINAMIDE SPECTROSCOPY INFRARED TG/DTG and TG/DTA BACTERICIDAL ACTIVITY
• 年，卷（期）: 2019,（2）
• 页码范围: 11-22
• 页数: 12页
• 分类号: O6

摘要

In this work, the isonicotinamide was coordinated to the Cobalt ion in oxidation state +2. The relevance of this work is the investigation of the in vitro bactericidal potential of the synthesized complex when tested in Gram-positive and negative bacteria strains. This study is motivated by the need to obtain new materials that have antibiotic properties and that, in the future, may become an effective drug against resistant bacteria. A new coordination compound of Cobalt and isonicotinamide, [Co(H2O)(isn)3](BF4)2, was synthesized and described. The compound was characterized by thermoanalytical techniques TG-DTG and TG-DSC, where it was possible to propose the mechanism of thermal decomposition. Through the spectroscopy in the region of the medium infrared (FTIR), it is possible to infer the site of connection between isonicotinamide and metal. The bactericidal activity of [Co(H2O)(isn)3](BF4)2, CoCl2 and free Isonicotinamide were tested for the bacteria Streptococcus mutans (Gram+) and Escherichia coli (Gram−) and the synthesized compound showed to be sensitive for both bacteria.