Treatment of Uncomplicated Recurrent Urinary Tract Infection with Chinese Medicine Formula: A Randomized Controlled Trial

• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2019,（1）
• 页码范围: 16-22
• 页数: 7页
• 语种: 英文
• DOI: 10.1007/s11655-017-2960-4

摘要

Objective:To evaluate Chinese medicine (CM) formula Bazheng Powder（八正散） as an alternative therapeutic option for female patients with recurrent urinary tract infection (RUTI).Methods:A randomized double-blinded trial was performed.Eligible female patients with RUTI were recruited from one hospital and two community health centers.By using a blocked randomization scheme,participants were randomized to receive a CM formula (10 herbs) and antibiotics placebo for 4 weeks,or antibiotics for 1 week followed by 3 weeks of placebo and CM formula placebo.Clinical cure rate and microbiological cure and recurrence after treatment were evaluated.Results:A total 122 eligible patients were enrolled,with 61 cases in each group.The clinical cure rate by the intent-to-treatment approach was 90.2％ for the CM group and 82.0％ for the antibiotics group (P＞0.05).Bacteria were cleared from 88.5％ (54/61) of patients in the CM group and 82.0％ (50/61) in the antibiotics group.The recurrence rate in recovered patients at the 6-month follow-up was 9.1％ (5/61) and 14.0 (7/61) in the CM and antibiotics groups,respectively (P＞0.05).Conclusion:CM formula Bazheng Powder is a good alternative option for RUTI treatment.(Registration No.NCT01745328)