Flu DRiPs in MHC Class Ⅰ Immunosurveillance

• 来源期刊: 中国病毒学
• 年，卷（期）: 2019,（2）
• 页码范围: 162-167
• 页数: 6页
• 语种: 英文

摘要

Since the publication of the DRiP (defective ribosomal product) hypothesis in 1996,numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8+ T cell immunosurveillance.Here,we review studies characterizing the generation of antigenic peptides from influenza A virus encoded DRiPs,discuss the many remaining mysteries regarding the nature of their co-translational generation,and speculate on where the future might lead.