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摘要:
Introduction. Exercise training has been effective in improving endothelial function and decreasing arterial stiffness in several systemic autoimmune diseases. However, to date, no studies have assessed patients with systemic autoimmune myopathies (SAM). Methods. Five female patients with definite SAM (3 dermatomyositis and 2 polymyositis) who underwent a 12-week, twice-a-week, exercise training program were assessed prospectively. The following parameters were assessed: endothelial function measured by flow-mediated dilatation (FMD), carotid femoral by pulse wave velocity (PWV), disease status by International Myositis Assessment & Clinical Studies Group (IMACS) set score, the ventilatory anaerobic threefold (VAT), respiratory compensation point (RCP), maximum effort (ME), maximal oxygen uptake (VO2max) measured by ergospyrometer, and strength and muscle function. Results. Mean age of the patients and duration of disease were 43.9 and 10.5 years, respectively. The median FMD and PWV were 10.2% and 7.1 m/s. After exercise training, important FMD reduction was observed in 4 out of 5 patients, whereas the PWV parameters decreased in only 2 out of 5 patients. The exercise training was safe, without clinical intercurrences or disease relapses. Moreover, an increase in strength and functionality was observed. Concerning aerobic capacity, there was a decrease in the VAT and an increase in ME, without al-terations in the maximum oxygen consumption. Conclusions. In general, exercise training does not alter endothelial function and PWV values, but improves muscle strength and function and also, does not lead to disease reactivation (Clinical Trials (NCT03092167)).
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篇名 Effects of Exercise Training on Endothelial Function, Arterial Structure, and Physical Conditioning in Patients with Systemic Autoimmune Myopathies: A Case Series Study
来源期刊 风湿病与自身免疫疾病期刊(英文) 学科 医学
关键词 DERMATOMYOSITIS ENDOTHELIAL Function Exercise POLYMYOSITIS Pulse Wave Velocity
年,卷(期) 2019,(2) 所属期刊栏目
研究方向 页码范围 57-68
页数 12页 分类号 R5
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DERMATOMYOSITIS
ENDOTHELIAL
Function
Exercise
POLYMYOSITIS
Pulse
Wave
Velocity
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研究去脉
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风湿病与自身免疫疾病期刊(英文)
季刊
2163-9914
武汉市江夏区汤逊湖北路38号光谷总部空间
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