Intercalated kaolinite as an emerging platform for cancer therapy

• 来源期刊: 中国科学:化学（英文版）
• 年，卷（期）: 2019,（1）
• 页码范围: 58-61
• 页数: 4页
• 语种: 英文

摘要

An innovative cancer therapy strategy regarding the interface engincering of kaolinite has been designed.The exposed silanol group facilitates more guest species with high dispersion on the supports.Mn3O4 magnetic nanoparticles are uniformly distributed on extemal surfaces of the KaolinC12N with the Al-O-Mn bond for the detection of the tumor microenvironment by T1-MRI;Doxorubicin (DOX) are loaded in the interlayer space with the electrostatic interaction for chemo--treating;and KI is coated on the outer layer of the nanocomposites based on the electrostatic interaction for thyroid cancer targeting.The synergetic effects and the treatment mechanism enhanced by the interface engineering,KI@DOX-Mn3O4-KaolinC12N can cause remarkably low cell viability (57％,200 μg/mL),tumor shrinking (75％,20 μg/kg),and accumulation into the tumor tissues.The novel kaolinite based drug delivery system is expected to incorporate imaging diagnosis,targeted therapy and drug delivery into one single system for postoperative residual thyroid cancer treatment and observation for metastasis of focal area.