Nucleosides 10: Synthesis of New Derivatives of Pyrimidine and Fused Pyrimidine Nucleosides of Expected Biological Activity

• 作者: Fatma E. M. Eibaih Laila M. Break Mosselhi A. M. Mohamed Ohoud A. A. Al-Thubaiti
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Synthesis NUCLEOSIDES PYRIMIDINES FUSED PYRIMIDINES HETEROCYCLES Biological Activity
• 年，卷（期）: 2019,（3）
• 页码范围: 107-120
• 页数: 14页
• 分类号: O6

摘要

Pyrimidines, such as 6-amino-2-thio and 2-methylthiouracils and fused pyrimidines, such as thienopyrimidines reacted with 1-O-acetyl-2,3,5-tri-O- benzoyl-β-D-ribofuranose to get new derivatives of the corresponding nucleosides. The obtained protected nucleosides were deprotected by methanolic sodium methoxide to get the corresponding free uracil and thienopyrimidine nucleosides. The new nucleosides formed were tested for biological activity against some of microorganism (some fungi and bacteria species). Some of the tested products showed moderate activity and the results were reported.