Synthesis of 2-Amino-4,6-dimethoxypyrimidine (ADM)

• 作者: Liang Hai Wang Wanting
• 来源期刊: Plant Diseases and Pests(植物病虫害研究:英文版)
• 学科: 农学
• 关键词: 2-amino-4 6-dimethoxypyrimidine (ADM) PYRILAMINE
• 年，卷（期）: 2019,（2）
• 页码范围: 1-3
• 页数: 3页
• 分类号: S

摘要

Using malononitrile as the raw material, a novel synthesis route of 2-amino-4,6-dimethoxypyrimidine (ADM) was put forward, in order to solve the instability in first step reaction of industrial synthesis. The influence of reactant ratio, temperature and time on product quality and yield was explored. The results showed that ADM was successfully prepared through acetyl chloride route, the yield was higher than that of industrial production process, and the process stability was good, with the product purity over 99%. Therefore, the new synthesis route is suitable for industrial production.