Anti-Zika virus RNAi in neural progenitor cells

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2019,（4）
• 页码范围: 261-262
• 页数: 2页
• 语种: 英文

摘要

Zika virus (ZIKV),a flavivirus that is primarily transmitted by mosquitoes,can cause devastating microcephaly and other congenital syndromes in infants born to infected pregnant women.In a recent paper in Cell Research,Xu et al.present data demonstrating that (i) ZlKV infection induces RNA interference (RNAi)-mediated antiviral defense in human neural progenitor cells and (ii) treatment with enoxacin,a broad-spectrum antibiotic with known RNAi-enhancing activity,prevents ZIKV infection and microcephalic defect in brain organoids.