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摘要:
Abnormal levels of plasma lipid have been linked to atherosclerosis, strokes and heart conditions. Variations in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels are considered as risk factors for coronary artery disease (CAD). Furthermore, triglycerides are a leading cause of cardiovascular disease. Therefore, measurement of plasma lipid levels is an important mortality predictor. Several factors were associated with irregularity in plasma lipids such as genetic alterations. Recent researches have linked single nucleotides polymorphism (SNP) in ApoA5 gene with these deviations. In this study, we reported the effects of the genetic variant c.553G>T in ApoA5 on the levels of plasma lipids. To explore these effects, a case-control study including 280 male and female subjects (44 of them were assigned as CAD cases while the remaining subjects were categorized as control) was established. All patients in the study were recruited from the western region in KSA. The results have detected minor variations in LDL, HDL and cholesterol levels between CAD patients carrying T allele and CAD patients carrying the WT allele. However, there were no significant effects due to these variations. TG levels in the wild type carriers reached up to 291 mg/dl while T allele carriers, the cases, presented lower levels of TG (170 mg/dl and 71 mg/dl). Although, T allele showed no effects on plasma lipids with the exception of TG levels. We suggest by this study that T allele in this SNP might be considered as a valuable tool in the diagnosis of CAD.
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遵义汉族载脂蛋白A5(c.553G/T)基因多态性与高甘油三酯血症
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c.553G/T多态
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中医痰证与APOA5基因c.553G》T多态性的关系研究
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冠状动脉疾病
载脂蛋白A类
多态性,单核苷酸
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篇名 The Genetic Variant c.553G>T in the Lipoprotein A5 Effects on Lipid Profile Parameters Levels
来源期刊 心血管病(英文) 学科 医学
关键词 APOA5 Gene Polymorphism Genetic Variation Coronary Artery Disease KINGDOM of SAUDI ARABIA (KSA)
年,卷(期) 2019,(2) 所属期刊栏目
研究方向 页码范围 122-131
页数 10页 分类号 R5
字数 语种
DOI
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研究主题发展历程
节点文献
APOA5
Gene
Polymorphism
Genetic
Variation
Coronary
Artery
Disease
KINGDOM
of
SAUDI
ARABIA
(KSA)
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
心血管病(英文)
月刊
2164-5329
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
224
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0
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0
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