The Genetic Variant c.553G>T in the Lipoprotein A5 Effects on Lipid Profile Parameters Levels

• 作者: Ahmed Fawzy Amr A. Amin Anas Dannoun Ashwag Aljohani Atalla Elsayed Dareen Ibrahim Rednah Faisal A. Al-Allaf Francesco Alamanni Massimo Porqueddu Mohiuddin M. Taher Neda M. Bogari Osama Elkhatee
• 来源期刊: 心血管病(英文)
• 学科: 医学
• 关键词: APOA5 Gene Polymorphism Genetic Variation Coronary Artery Disease KINGDOM of SAUDI ARABIA (KSA)
• 年，卷（期）: 2019,（2）
• 页码范围: 122-131
• 页数: 10页
• 分类号: R5

摘要

Abnormal levels of plasma lipid have been linked to atherosclerosis, strokes and heart conditions. Variations in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels are considered as risk factors for coronary artery disease (CAD). Furthermore, triglycerides are a leading cause of cardiovascular disease. Therefore, measurement of plasma lipid levels is an important mortality predictor. Several factors were associated with irregularity in plasma lipids such as genetic alterations. Recent researches have linked single nucleotides polymorphism (SNP) in ApoA5 gene with these deviations. In this study, we reported the effects of the genetic variant c.553G>T in ApoA5 on the levels of plasma lipids. To explore these effects, a case-control study including 280 male and female subjects (44 of them were assigned as CAD cases while the remaining subjects were categorized as control) was established. All patients in the study were recruited from the western region in KSA. The results have detected minor variations in LDL, HDL and cholesterol levels between CAD patients carrying T allele and CAD patients carrying the WT allele. However, there were no significant effects due to these variations. TG levels in the wild type carriers reached up to 291 mg/dl while T allele carriers, the cases, presented lower levels of TG (170 mg/dl and 71 mg/dl). Although, T allele showed no effects on plasma lipids with the exception of TG levels. We suggest by this study that T allele in this SNP might be considered as a valuable tool in the diagnosis of CAD.