Mannich-Type Reaction of Aldimines with 2-Silyloxydienes Catalyzed by Ammonium Chloride

• 作者: Kaori Ishimaru Miho Shigenobu Shoichi Fukumoto
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Mannich-Type Reaction AMMONIUM CHLORIDE IMINE 2-Silyloxydiene
• 年，卷（期）: yjhxgjqkyw_2019,（4）
• 页码范围: 163-173
• 页数: 11页
• 分类号: O62

摘要

Reaction of imines with 2-silyloxydiene catalyzed by ammonium chloride has been perfectly proceeded under environmentally friendly conditions to give Mannich-type product selectively. The reaction would proceed via Mannich-type mechanism, not cyclization/ring-opening process. Cyclopropanation of the corresponding Mannich-type product gave the precursor of prasugrel skeleton in high yield.