Automated Exudates Detection in Retinal Fundus Image Using Morphological Operator and Entropy Maximization Thresholding

• 作者: A. B. Tiedeu B. C. Wouantsa Tindo G. H. Kom J. R. Mboupda Pone
• 来源期刊: 生物医学工程(英文)
• 学科: 医学
• 关键词: Diabetic RETINOPATHY RETINAL FUNDUS Image EXUDATES Entropy MAXIMIZATION THRESHOLDING
• 年，卷（期）: 2019,（3）
• 页码范围: 212-224
• 页数: 13页
• 分类号: R73

摘要

Blindness which is considered as degrading disabling disease is the final stage that occurs when a certain threshold of visual acuity is overlapped. It happens with vision deficiencies that are pathologic states due to many ocular diseases. Among them, diabetic retinopathy is nowadays a chronic disease that attacks most of diabetic patients. Early detection through automatic screening programs reduces considerably expansion of the disease. Exudates are one of the earliest signs. This paper presents an automated method for exudates detection in digital retinal fundus image. The first step consists of image enhancement. It focuses on histogram expansion and median filter. The difference between filtered image and his inverse reduces noise and removes background while preserving features and patterns related to the exudates. The second step refers to blood vessel removal by using morphological operators. In the last step, we compute the result image with an algorithm based on Entropy Maximization Thresholding to obtain two segmented regions (optical disk and exudates) which were highlighted in the second step. Finally, according to size criteria, we eliminate the other regions obtain the regions of interest related to exudates. Evaluations were done with retinal fundus image DIARETDB1 database. DIARETDB1 gathers high-quality medical images which have been verified by experts. It consists of around 89 colour fundus images of which 84 contain at least mild non-proliferative signs of the diabetic retinopathy. This tool provides a unified framework for benchmarking the methods, but also points out clear deficiencies in the current practice in the method development. Comparing to other recent methods available in literature, we found that the proposed algorithm accomplished better result in terms of sensibility (94.27%) and specificity (97.63%).