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Today,many next-generation sequencing (NGS) methods,technologies and platforms have been developed that allow users to produce Tera base pairs of data in less than one day or ultralong reads covering multiple genes.By far the most popular NGS approach to date is cyclic sequencing-by-synthesis (SBS),whereby each DNA template's complementary strand is synthesized by DNA polymerase and,as the new strand grows base by base,the identity of each incorporated dNTP is detected via different chemistries or modalities.Existing variations on this SBS approach each has its strengths,but also each comes with trade-offs:modalities with high accuracy often suffer from reduced sequencing speed or read length;others can achieve long read length but at the cost of accuracy.In their recent Nature Biotechnology publication [1],Chen and colleagues give the classical SBS method an innovative head-to-toe makeover that could mean yet another quantum leap in sequencing speed,accuracy,and cost reduction.
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篇名 A head-to-toe makeover for classical sequencing-by-synthesis helps users to squeeze more out of each base
来源期刊 国家科学评论(英文版) 学科
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年,卷(期) 2019,(1) 所属期刊栏目
研究方向 页码范围 3-4
页数 2页 分类号
字数 语种 英文
DOI 10.1093/nsr/nwy013
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期刊影响力
国家科学评论(英文版)
月刊
2095-5138
10-1088/N
大16开
北京市
80-671
2014
eng
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773
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0
总被引数(次)
431
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