ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumor suppressor functions
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摘要:
A multi-laboratory research team led by Prof.Feng XinHua (冯新华) in the Life Sciences Institute,Zhejiang University has recently reported a novel mechanism underlying TGF-β resistance in ALK-positive tumors (Nature Cell Biology,2019,21:179-189).The study was conducted with support from the National Natural Science Foundation of China and other supports.