Acute onset clozapine-induced hyperglycaemia: A case report

• 作者: Dheerendra Kumar Mishra Gyanendra Raghuvanshi Nimisha Mishra Pradeep Kumar Sunil Ahuja Vijay Niranjan
• 来源期刊: 综合精神医学(英文)
• 学科: 医学
• 关键词: CLOZAPINE ATYPICAL ANTIPSYCHOTIC ANTIPSYCHOTIC MEDICATIONS
• 年，卷（期）: 2019,（2）
• 页码范围: 95-96
• 页数: 2页
• 分类号: R

摘要

Clozapine is an atypical antipsychotic which is described to have higher efficacy among all available antipsychotic medications. Clozapine is reserved especially for resistant schizophrenia due to its side effects. Clozapine-induced metabolic syndrome and hyperglycaemia are common longterm side effects and are responsible for increased mortality in patients with schizophrenia. In this case, a patient with resistant schizophrenia was presented with acute-onset hyperglycaemia and delirium with the use of clozapine within a week. Withdrawal of clozapine in the patient led to the improvement in delirium and hyperglycaemia without the use of any hypoglycaemic agent. This case s叩ports the notion that in certain cases clozapine can induce hyperglycemia through possible direct pathophysiological mechanisms within a shorter time frame.