Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma

• 来源期刊: 药学学报（英文版）
• 关键词: Na(i)ve neutrophils membrane Celastrol PEG-PLGA nanoparticle Pancreatic carcinoma Inflammation
• 年，卷（期）: 2019,（3）
• 页码范围: 575-589
• 页数: 15页
• 语种: 英文

摘要

Due to the critical correlation between inflammation and carcinogenesis,a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy.Here,we report the therapeutic efficacy of celastrol as a promising candidate compound for treatment of pancreatic carcinoma via na(i)ve neutrophil membrane-coated poly(ethylene glycol) methyl ether-block-poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles.Neutrophil membrane-coated nanoparticles (NNPs) are well demonstrated to overcome the blood pancreas barrier to achieve pancreas-specific drug delivery in vivo.Using tumor-bearing mice xenograft model,NNPs showed selective accumulations at the tumor site following systemic administration as compared to nanoparticles without neutrophil membrane coating.In both orthotopic and ectopic tumor models,celastrol-loaded NNPs demonstrated greatly enhanced tumor inhibition which significantly prolonged the survival of tumor bearing mice and minimizing liver metastases.Overall,these results suggest that celastrol-loaded NNPs represent a viable and effective treatment option for pancreatic carcinoma.