Null links between vitamin B6 and B12 intake and occurrence risk of lung cancer: a meta-analysis

• 作者: Li-Ping Shen Rong Li Ya-Juan Cao
• 来源期刊: TMR肿瘤
• 学科: 医学
• 关键词: VITAMIN B Lung cancer Incidence VITAMIN B6 VITAMIN B12
• 年，卷（期）: 2019,（4）
• 页码范围: 252-260
• 页数: 9页
• 分类号: R73

摘要

Vitamin B6 and B12 are involved in many biochemical reactions and might play arole in carcinogenesis. We summarized the evidences linking vitamin B6 and B12to occurrence risk of lung cancer and conducted a meta-analysis of the relationshipbetween vitamin B6 and B12 intake and the risk of lung cancer. Fixed-effectmeta-analysis was used to calculate pooled relative risks (RRs) and their 95%confidence intervals (CIs). We identified four observational studies (participants, n= 206,290;cases, n = 1,134) and three randomized controlled trials (RCTs;participants, n = 97,569;cases, n = 952). Vitamin B6 and B12 supplementary wasnot statistically significantly associated with occurrence risk of lung cancer(124/11926 (1.04%) vs. 73/8497 (0.86%), RR = 1.06, 95% CI = 0.78-1.43, P =0.71). A consistent association was also observed, findings from RCTs did notsupport a protective effect of vitamin B6 and B12intake orally decrease the risk oflung cancer occurrence (HR = 1.13, 95% CI = 0.86-1.50, P = 0.39). For thewomen, there was no confirmed evidence demonstrated vitamin B intake candecrease the occurrence risk of lung cancer across the subgroup analyses (HR =0.96, 95% CI = 0.80-1.16, P = 0.99). Dietary vitamin B6 and B12 intake also hadno influence on occurrence risk of lung cancer in difference doses and intakeduration. In conclusion, no confirmed links were found between vitamin B6 andB12 intake and risk of lung cancer occurrence.