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摘要:
We aimed to evaluate the current nationwide trend,efficacy,safety,and quality of life (QoL) profiles of hormone treatment in real-world practice settings for prostate cancer (PCa) patients in Korea.A total of 292 men with any biopsy-proven PCa (TanyNanyMany)from 12 institutions in Korea were included in this multi-institutional,observational study of prospectively collected data.All luteinizing hormone-releasing hormone (LHRH) agonists were allowed to be investigational drugs.Efficacy was defined as (1) the rate of castration (serum testosterone ≤50 ng dl-1) at 4-week visit and (2) breakthrough (serum testosterone >50 ng dl-1 after castration).Safety assessments included routine examinations for potential adverse events,laboratory tests,blood pressure,body weight,and bone mineral density (BMD,at baseline and at the last follow-up visit).QoL was assessed using the Expanded Prostate Cancer Index Composite-26 (EPIC-26).The most common initial therapeutic regimen was LHRH agonist with anti-androgen (78.0%),and the most commonly used LHRH agonist for combination and monotherapy was leuprolide (64.0% for combination and 58.0% for monotherapy).The castration and breakthrough rates were 78.4% and 6.6%,respectively.The laboratory results related to dyslipidemia worsened after 4 weeks of hormone treatment.In addition,the mean BMD T-score was significantly lower at the last follow-up (mean:-1.950) compared to baseline (mean:-0.195).The mean total EPIC-26 score decreased from 84.8 (standard deviation [s.d.]:12.2) to 78.3 (s.d.:8.1),with significant deterioration only in the urinary domain (mean:23.5 at baseline and 21.9 at the 4-week visit).These findings demonstrate the nationwide trend of current practice settings in hormone treatment for PCa in Korea.
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篇名 The current status of hormone treatment for prostate cancer patients in Korean real-world practice: a multi-institutional observational study
来源期刊 亚洲男性学杂志(英文版) 学科
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年,卷(期) 2019,(2) 所属期刊栏目
研究方向 页码范围 115-120
页数 6页 分类号
字数 语种 英文
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期刊影响力
亚洲男性学杂志(英文版)
双月刊
1008-682X
31-1795/R
大16开
上海市太原路294号16号楼302室
4-648
1999
eng
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2771
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总被引数(次)
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