Virtual screening of active ingredients,potential targets and pathways from Elephantopus scaber L.against liver cancer based on network pharmacology

• 作者: Ming Bai Shaojiang Song Shuhui Dong Xiaoxiao Huang
• 来源期刊: 亚洲传统医药
• 学科: 医学
• 关键词: Elephantopus scaber L. network PHARMACOLOGY LIVER cancer
• 年，卷（期）: 2019,（6）
• 页码范围: 260-267
• 页数: 8页
• 分类号: R73

摘要

Elephantopus scaber L.,belonging to Elephantopus plant of Compositae,is widely used as the common Chinese herbal medicine in folk.According to the phytochemical investigations,E.scaber is used to treat several cancers,anemia and diarrhea on account of the property of the complex components and multi-targets.However,the underlying molecular mechanisms of herb remain unclear.In this report,network pharmacology method is used to analyze the relation among the small-molecule compounds of E.scaber,target proteins,biological pathways and liver cancer.The potential active compounds from the E.scaber,potential target proteins and the key pathways were predicted by network pharmacology models.We believe that our present study is useful to find novel lead compounds for liver cancer.